Bioactivity:

MS2177 is a potent and selective inhibitor of SETD8, the only methyltransferase known to catalyze monomethylation of histone H4 lysine 20 (H4K20). MS2177 has an in vitro IC50 of 1.9 _M (_ = 1.05 _M, n = 4) in ascintillation proximity assay. Binding of MS2

CAS nr:

T28114

Purity:

98%

Molecular Weight:

442,61

SMILES:

COC1=C(OCCN)C=C(N=C(N2CCCC2)N=C3NCCCCCN4CCCC4)C3=C1

Formula:

C24H38N6O2

Pathway:

Target: