Bioactivity:

ARV-825, a heterobifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon leading to fast, efficient, and prolonged degradation of BRD4 in all BL cell lines tested.

CAS nr:

1818885-28-7

Purity:

98%

Molecular Weight:

923,43

SMILES:

O=C1NC(=O)CCC1N8C(=O)c7cccc(NCCOCCOCCOCCOc2ccc(cc2)NC(=O)C[C@@H]5N=C(c3ccc(Cl)cc3)c6c(C)c(C)sc6n4c(C)nnc45)c7C8=O

Formula:

C46H47ClN8O9S

Pathway:

Chromatin/Epigenetic

Target:

Epigenetic Reader Domain