Bioactivity:

Roniciclib is a potent pan-CDK inhibitor and a novel oral cytotoxic agent. Roniciclib inhibits the activity of cell-cycle CDKs CDK1, CDK2, CDK3, CDK4, and of transcriptional CDKs CDK7 and CDK9 with IC(50) values in the range between 5 and 25 nmol/L.

CAS nr:

1223498-69-8

Purity:

98%

Molecular Weight:

430,44

SMILES:

C[C@@H](O)[C@H](OC1=NC(NC2=CC=C([S@@](=N)(C3CC3)=O)C=C2)=NC=C1C(F)(F)F)C

Formula:

C18H21F3N4O3S

Pathway:

Cell Cycle/Checkpoint

Target:

CDK