Bioactivity:

Bafetinib (INNO-406) is an effective and specific dual Bcr-Abl/Lyn inhibitor (IC50: 5.8/19 nM), and no inhibition of the phosphorylation of the T315I mutant and less effective to c-Kit and PDGFR.

CAS nr:

859212-16-1

Purity:

98%

Molecular Weight:

576,62

SMILES:

CN(C)[C@H]1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cncnc3)c2)C1

Formula:

C30H31F3N8O

Pathway:

Angiogenesis,Tyrosine Kinase/Adaptors,Tyrosine Kinase/Adaptors,Angiogenesis,Autophagy,Cytoskeletal Signaling

Target:

Bcr-Abl,Bcr-Abl,Src,Src,Autophagy,Bcr-Abl