Bioactivity:

Afatinib is an irreversible inhibitor of EGFR family (EGFR-wt, EGFR-L858R, EGFR-L858R/T790M and HER2 with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM , respectively).

CAS nr:

850140-72-6

Purity:

98%

Molecular Weight:

485,94

SMILES:

O=C(NC1=C(C=C2C(C(NC3=CC(Cl)=C(C=C3)F)=NC=N2)=C1)O[C@]4CCOC4)/C=C/CN(C)C

Formula:

C24H25ClFN5O3

Pathway:

Angiogenesis,JAK/STAT signaling,Autophagy,Tyrosine Kinase/Adaptors

Target:

EGFR,EGFR,Autophagy,EGFR