Bioactivity:

Terevalefim (ANG-3777), an hepatocyte growth factor (HGF) mimetic, selectively activates the c-Met receptor[1][2]. Terevalefim (ANG-3777) (0-10 _M) significantly inhibited cancer cells proliferation in HUVECs[2]. Terevalefim (ANG-3777) decreases apoptosis, increases proliferation, and promotes organ repair and function in animal models[1].Terevalefim (ANG-3777, 40 mg/kg, IP) phosphorylates the c-Met receptor in rats[2]. [1]. Jonathan S Bromberg, et al. Renal Function Improvement Following ANG-3777 Treatment in Patients at High Risk for Delayed Graft Function After Kidney Transplantation. Transplantation. 2021 Feb 1;105(2):443-450.[2]. Latha Paka, et al. The Effect of ANG-3777 on Hepatocyte Growth Factor Receptor, c-MET Signaling. American Transplant Society.

CAS nr:

1070881-42-3

Purity:

98%

Molecular Weight:

176,24

SMILES:

N/A

Formula:

C9H8N2S

Pathway:

Target: