Bioactivity:

Mutated EGFR-IN-3 is a ATP-competitive and highly selective allosteric dibenzodiazepinone EGFR(L858R/T790M) and EGFR(L858R/T790M/C797S) inhibitor(IC50 of 12 nM and 13 nM, respectively. )

CAS nr:

2375107-27-8

Purity:

98%

Molecular Weight:

508,59

SMILES:

O=C1C2=CC(OC3=CC=C(N4CCN(C)CC4)C=C3)=CC=C2NC5=CC=C(F)C=C5N1CC6=CC=CC=C6

Formula:

C31H29FN4O2

Pathway:

Tyrosine Kinase/Adaptors,Angiogenesis,JAK/STAT signaling

Target:

EGFR,EGFR,EGFR