Bioactivity:

Selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1_, but not HIF-2_, with HIF-1_ (IC50 = 1.3 _M). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cance

CAS nr:

1446322-66-2

Purity:

98%

Molecular Weight:

2559,1

SMILES:

Formula:

C111H188N42O24S2

Pathway:

Target: