Bioactivity:

(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).

CAS nr:

T12798

Purity:

98%

Molecular Weight:

1096,31

SMILES:

O=C([C@H](C[C@H](O)C1)N1C([C@@H](NC(CCCCCCCCCCNC(C2=C(CS(=O)(C)=O)C=C(C(N(C3=NC=C(F)C=C3F)C4)=C2)C5=CN(C)C(C6=C5C4=CN6)=O)=O)=O)C(C)(C)C)=O)NCC7=CC=C(C(SC=N8)=C8C)C=C7

Formula:

C56H67F2N9O8S2

Pathway:

Chromatin/Epigenetic

Target:

Epigenetic Reader Domain