Bioactivity:

Avacopan is an orally administered small-molecule C5aR (�IC50 : 0.1 nM.)antagonist that blocks the effects of C5a and prevents the development of GN induced by anti-myeloperoxidase antibodies in a murine model of AAV.

CAS nr:

1346623-17-3

Purity:

98%

Molecular Weight:

581,6

SMILES:

Cc1ccc(NC(=O)[C@H]2CCCN([C@H]2c2ccc(NC3CCCC3)cc2)C(=O)c2c(C)cccc2F)cc1C(F)(F)F

Formula:

C33H35F4N3O2

Pathway:

Immunology/Inflammation

Target:

Complement System