Bioactivity:

4-CPPC is an inhibitor of macrophage migration inhibitory factor-2 (MIF-2; IC50= 27 _M).1It is selective for MIF-2 over MIF-1 (IC50= 450 _M). It inhibits MIF-2, but not MIF-1, binding to CD74in vitrowhen used at a concentration of 10 _M. 4-CPPC (5, 10, and 25 _M) inhibits MIF-2-induced ERK1/2 phosphorylation in primary human skin fibroblasts. 1.Tilstam, P.V., Pantouris, G., Corman, M., et al.A selective small-molecule inhibitor of macrophage migration inhibitory factor-2 (MIF-2), a MIF cytokine superfamily member, inhibits MIF-2 biological activityJ. Biol. Chem.294(49)18522-18531(2019)

CAS nr:

29553-70-6

Purity:

98%

Molecular Weight:

287,227

SMILES:

OC(=O)c1cccc(c1)-c1cc(ncc1C(O)=O)C(O)=O

Formula:

C14H9NO6

Pathway:

Target: