Bioactivity:

Duocarmycin A, an antitumor antibiotic, is a DNA alkylator and efficiently alkylates adenine N3 at the 3_ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results in HLC-2 cells typically apoptotic changes.

CAS nr:

118292-34-5

Purity:

98%

Molecular Weight:

507,49

SMILES:

O=C([C@@](N1)(C)C(C([C@@]23[C@@](C3)([H])CN(C(C(N4)=CC5=C4C(OC)=C(OC)C(OC)=C5)=O)C2=C6)=C1C6=O)=O)OC

Formula:

C26H25N3O8

Pathway:

Proteases/Proteasome,Apoptosis

Target:

Caspase,Caspase