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Bioactivity:
AMG 458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells.
CAS nr:
913376-83-7
Purity:
98%
Molecular Weight:
539,58
SMILES:
COC1=CC2=NC=CC(OC3=CN=C(NC(=O)C4=C(C)N(CC(C)(C)O)N(C4=O)C4=CC=CC=C4)C=C3)=C2C=C1
Formula:
C30H29N5O5
Pathway:
Tyrosine Kinase/Adaptors
Target:
c-Met/HGFR