Bioactivity:

CAY10781 is an inhibitor of the protein-protein interaction between neuropilin-1 (NRP-1) and VEGF-A.1It inhibits the interaction by 43% when used at a concentration of 12.5 _M. CAY10781 also inhibits VEGF-A-induced phosphorylation of VEGFR2 in catecholamine A-differentiated (CAD) cells when used at the same concentration. 1.Perez-Miller, S., Patek, M., Moutal, A., et al.In silico identification and validation of inhibitors of the interaction between neuropilin receptor 1 and SARS-CoV-2 Spike proteinbioRxiv308783(2020)

CAS nr:

1210360-87-4

Purity:

98%

Molecular Weight:

231,211

SMILES:

OC(=O)Cc1cnc([nH]c1=O)-c1cccnc1

Formula:

C11H9N3O3

Pathway:

Target: