Bioactivity:

GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to other protein kinases.

CAS nr:

1116235-97-2

Purity:

98%

Molecular Weight:

532,57

SMILES:

c1(nc(nc2c1cc[nH]2)Nc1c(cc2c(c1)N(CC2)C(=O)CN(C)C)OC)Nc1c(c(ccc1)F)C(=O)NC

Formula:

C27H29FN8O3

Pathway:

Tyrosine Kinase/Adaptors,Angiogenesis,MAPK,Tyrosine Kinase/Adaptors,MAPK,PI3K/Akt/mTOR signaling

Target:

ALK,ALK,JNK,IGF-1R,S6 Kinase,S6 Kinase