Bioactivity:

PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.2

CAS nr:

2098487-75-1

Purity:

98%

Molecular Weight:

852,94

SMILES:

O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3OCC(NCCCCN4C=C(COC5=CC(CC6=CN=C(NC(CSC7=NC(C)=CC(C)=N7)=O)S6)=CC=C5)N=N4)=O

Formula:

C40H40N10O8S2

Pathway:

DNA Damage/DNA Repair,Chromatin/Epigenetic

Target:

Sirtuin,Sirtuin