Bioactivity:

(-)-PX20606 trans isomer is an agonist of FXR (EC50s: 18 and 29 nM for FXR in FRET and M1H assay, respectively).

CAS nr:

1268244-88-7

Purity:

98%

Molecular Weight:

554,85

SMILES:

ClC1=C(C2=NOC(C3CC3)=C2COC4=CC=C([C@@H]5C[C@H]5C6=CC=C(C(O)=O)C=C6)C(Cl)=C4)C(Cl)=CC=C1.[(-)].[Rotation]

Formula:

C29H22Cl3NO4

Pathway:

Metabolism

Target:

FXR