Product overview:

ENG (CD105) mouse monoclonal antibody, clone LBI6G8

Field of research:

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Summary:

This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Alternative names:

END; HHT1; ORW1

Species reactivity:

Human

Host:

Mouse

Target:

ENG

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human ENg(NP_000109) produced in HEK293T cell.

Clone:

LBI6G8

Conjugation:

Unconjugated

Gene name:

endoglin

Symbol:

ENG

Pathway:

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Function:

Druggable Genome, ES Cell Differentiation/IPS, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IF 1:100

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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