Product overview:

CDKN2B (p15 INK4b) mouse monoclonal antibody, clone LBI7C4

Field of research:

Cell cycle, Pathways in cancer, Small cell lung cancer, TGF-beta signaling pathway

Summary:

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq]

Alternative names:

CDK4I; INK4B; MTS2; P15; p15INK4b; TP15

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

CDKN2B

Isotype:

IgG2b

Immunogen:

Full length human recombinant protein of human CDKN2B(NP_004927) produced in HEK293T cell.

Clone:

LBI7C4

Conjugation:

Unconjugated

Gene name:

cyclin dependent kinase inhibitor 2B

Symbol:

CDKN2B

Pathway:

Cell cycle, Pathways in cancer, Small cell lung cancer, TGF-beta signaling pathway

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com