Product overview:

OTUB1 mouse monoclonal antibody, clone LBI5B8

Field of research:

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Summary:

The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq]

Alternative names:

HSPC263; OTB1; OTU1

Species reactivity:

Human, Rat

Host:

Mouse

Target:

OTUB1

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human OTUB1(NP_060140) produced in HEK293T cell.

Clone:

LBI5B8

Conjugation:

Unconjugated

Gene name:

OTU deubiquitinase, ubiquitin aldehyde binding 1

Symbol:

OTUB1

Pathway:

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Function:

Protease

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IHC 1:150, FLOW 1:100

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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