Product overview:

APP (Amyloid beta precursor protein) mouse monoclonal antibody, clone LBI7B8

Field of research:

Alzheimer's disease

Summary:

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq]

Alternative names:

AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

APP

Isotype:

IgG2a

Immunogen:

Full length human recombinant protein of human APP(NP_000475) produced in HEK293T cell.

Clone:

LBI7B8

Conjugation:

Unconjugated

Gene name:

amyloid beta precursor protein

Symbol:

APP

Pathway:

Alzheimer's disease

Function:

Druggable Genome, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IHC 1:150

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com