Product overview:

RUNX1T1 (ETO) mouse monoclonal antibody, clone LBI1H1

Field of research:

Acute myeloid leukemia, Pathways in cancer

Summary:

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq]

Alternative names:

AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8; ZMYND2

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

RUNX1T1

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human RUNX1T1(NP_783553) produced in HEK293T cell.

Clone:

LBI1H1

Conjugation:

Unconjugated

Gene name:

RUNX1 partner transcriptional co-repressor 1

Symbol:

RUNX1T1

Pathway:

Acute myeloid leukemia, Pathways in cancer

Function:

Transcription Factors

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IF 1:100

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com