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ERCC1 Mouse Monoclonal Antibody [Clone ID: LBI3B1] AMM12385V
Specifications
| 100ul / 30ul |
Product overview:
ERCC1 mouse monoclonal antibody, clone LBI3B1
Field of research:
Nucleotide excision repair
Summary:
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq]
Alternative names:
COFS4; RAD10; UV20
Species reactivity:
Human, Mouse
Host:
Mouse
Target:
ERCC1
Isotype:
IgG2a
Immunogen:
Full length human recombinant protein of human ERCC1(NP_001974) produced in HEK293T cell.
Clone:
LBI3B1
Conjugation:
Unconjugated
Gene name:
ERCC excision repair 1, endonuclease non-catalytic subunit
Symbol:
ERCC1
Pathway:
Nucleotide excision repair
Function:
Druggable Genome
Purification:
Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Concentration:
1.07 mg/ml
Form:
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Applications & dilution:
WB 1:500~2000, IF 1:100, FLOW 1:100
Storage buffer:
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Storage:
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
More info:
Email: info@sobekbio.com
Orders:
Email: orders@sobekbio.com