Background:

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the m

Classification:

Primary antibody

Alternative names:

ERBB3; HER3; Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3

Species reactivity:

Human

Host:

Mouse

Isotype:

IgG

Immunogen:

Purified recombinant extracellular fragment of human ErbB-3 (aa22-369) fused with hIgGFc tag expressed in HEK293 cells.

Concentration:

1 mg/ml

Molecular weight:

N/A

Applications:

WB, IF, ICC, ELISA

Storage:

-20°C for one year

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