Background:

This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.

Classification:

Primary antibody

Alternative names:

Transthyretin; ATTR; Prealbumin; TBPA

Species reactivity:

Human

Host:

Mouse

Isotype:

IgG

Immunogen:

Recombinant Protein of TTR

Concentration:

1 mg/ml

Molecular weight:

N/A

Applications:

IF, ICC, WB, IHC-p

Storage:

-20°C for one year

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