Background:

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Classification:

Primary antibody

Alternative names:

Chromobox protein homolog 5; Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha

Species reactivity:

Human,Mouse,Rat

Host:

Mouse

Isotype:

IgG

Immunogen:

Recombinant Protein of HP-1α

Concentration:

1 mg/ml

Molecular weight:

N/A

Applications:

IF, ICC, WB, IHC-p

Storage:

-20°C for one year

More info:

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