Background:

The protein encoded by CLEC6A (C-type lectin domain family 6 member A) is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for CLEC6A.

Classification:

Primary antibody

Alternative names:

CLEC6A; CLECSF10; DECTIN2; C-type lectin domain family 6 member A; C-type lectin superfamily member 10; Dendritic cell-associated C-type lectin 2; DC-associated C-type lectin 2; Dectin-2

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from the Internal region of human Dectin-2.

Concentration:

1 mg/ml

Molecular weight:

23998

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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