Background:

CYP26B1 (cytochrome P450 family 26 subfamily B member 1) encodes a member of the cytochrome P450 superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein is localized to the endoplasmic reticulum, and functions as a critical regulator of all-trans retinoic acid levels by the specific inactivation of all-trans retinoic acid to hydroxylated forms. Mutations in CYP26B1 are associated with radiohumeral fusions and other skeletal and craniofacial anomalies, and increased levels of the encoded protein are associated with atherosclerotic lesions. Alternative splicing results in multiple transcript variants.

Classification:

Primary antibody

Alternative names:

CYP26B1 CYP26A2 P450RAI2

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthetic peptide from human protein at AA range: 391-440

Concentration:

1 mg/ml

Molecular weight:

57513

Applications:

WB, ELISA

Storage:

-20°C for one year

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