Background:

COL18A1 (collagen type XVIII alpha 1 chain) encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in COL18A1 are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants.

Classification:

Primary antibody

Alternative names:

COL18A1; Collagen alpha-1(XVIII) chain

Species reactivity:

Human;Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human Collagen XVIII alpha1. AA range:801-850

Concentration:

1 mg/ml

Molecular weight:

178160

Applications:

IHC-p, IF, ELISA

Storage:

-20°C for one year

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