Background:

The protein encoded by CD63 (CD63 molecule) is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also CD63 has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms.

Classification:

Primary antibody

Alternative names:

CD63; MLA1; TSPAN30; CD63 antigen; Granulophysin; Lysosomal-associated membrane protein 3; LAMP-3; Melanoma-associated antigen ME491; OMA81H; Ocular melanoma-associated antigen; Tetraspanin-30; Tspan-

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from the Internal region of human CD63. AA range:121-170

Concentration:

1 mg/ml

Molecular weight:

25637

Applications:

IF, WB, IHC-p, ELISA

Storage:

-20°C for one year

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