Background:

The leukocyte associated immunoglobulin like receptor 1 encoded by LAIR1 is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13. called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants.

Classification:

Primary antibody

Alternative names:

LAIR1; CD305; Leukocyte-associated immunoglobulin-like receptor 1; LAIR-1; hLAIR1; CD305

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from the Internal region of human LAIR1. AA range:21-70

Concentration:

1 mg/ml

Molecular weight:

31412

Applications:

WB, ELISA

Storage:

-20°C for one year

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