CD110 Polyclonal Antibody BT-AP01340
Specifications
| 20ul / 50ul / 100ul |
Background:
The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.
Classification:
Primary antibody
Alternative names:
MPL; TPOR; Thrombopoietin receptor; TPO-R; Myeloproliferative leukemia protein; Proto-oncogene c-Mpl; CD antigen CD110
Species reactivity:
Human
Host:
Rabbit
Isotype:
IgG
Immunogen:
Synthesized peptide derived from the Internal region of human CD110.
Concentration:
1 mg/ml
Molecular weight:
71245
Applications:
WB, ELISA
Storage:
-20°C for one year
More info:
Email: info@sobekbio.com
Orders:
Email: orders@sobekbio.com
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