Background:

The peptidase M14 family of carboxypeptidases (CPs) are involved in various functions throughout the body which include digestion of food and biosynthesis of peptides that function in intercellular signaling. CCP2 (cytosolic carboxypeptidase 2), also known as AGBL2 (ATP/GTP binding protein-like 2), is a 902 amino acid cytoplasmic protein belonging to the peptidase M14 family. CCP2 is considered a metallocarboxypeptidase that may play a role in the processing of tubulin. CCP2 binds one zinc ion per subunit as a cofactor and exists as three alternatively spliced isoforms. The gene encoding CCP2 is located on human chromosome 11p11.2. Chromosome 11 houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.

Classification:

Primary antibody

Alternative names:

AGBL2; CCP2; Cytosolic carboxypeptidase 2; ATP/GTP-binding protein-like 2

Species reactivity:

Human;Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human CBCP2. AA range:731-780

Concentration:

1 mg/ml

Molecular weight:

104176

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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