Background:

CASP10 encodes caspase 10 which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Classification:

Primary antibody

Alternative names:

CASP10; MCH4; Caspase-10; CASP-10; Apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1B-converting enzyme 2; FLICE2; ICE-like apoptotic protease 4

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from the Internal region of human Caspase-10.

Concentration:

1 mg/ml

Molecular weight:

58951

Applications:

WB, ELISA

Storage:

-20°C for one year

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