Background:

CASP1 encodes a protein (caspase 1) which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.

Classification:

Primary antibody

Alternative names:

caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)

Species reactivity:

Human;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from the C-terminal region of human CASP1. AA range:350-400

Concentration:

1 mg/ml

Molecular weight:

45159

Applications:

IF, WB, IHC-p, ELISA

Storage:

-20°C for one year

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