Alternative names:

AW047313;Dtr;Dts;Hegfl

Description:

Recombinant mouse HBEGF(24-160) protein with C-terminal 6×His tag

Background:

Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.[UniProtKB/Swiss-Prot Function]

Molecular characterization:

Mouse HBEGF(24-160)(Gln24-Thr160) 6×His tag

Molecular weight:

The protein has a predicted molecular mass of 16.0 kDa after removal of the signal peptide.The apparent molecular mass of mHBEGF(24-160)-His is approximately 25-35 kDa due to glycosylation.

Tag:

C-6×His Tag

Expression host:

HEK293

Target:

HBEGF

Purity:

The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.

Formulation / Reconstitution:

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.

Storage:

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

More info:

Email info@sobekbio.com

Orders:

Email orders@sobekbio.com