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Human TIM3 Protein, mFc-His Tag PME100030
Specifications
| 10µg / 50µg / 100µg |
Alternative names:
HAVCR2;TIM3;TIMD3;FLJ14428;KIM3
Description:
Recombinant human TIM3 protein with C-terminal mouse Fc and 6×His tag
Background:
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
Molecular characterization:
TIM3(Ser22-Gly202) mFc(Pro99-Lys330) 6×His tag
Molecular weight:
The protein has a predicted molecular mass of 47.5 kDa after removal of the signal peptide.
Tag:
C-Mouse Fc and 6×His Tag
Expression host:
HEK293
Target:
TIM3
Purity:
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation / Reconstitution:
Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
More info:
Email info@sobekbio.com
Orders:
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