Alternative names:

TNFRSF9;4-1BB;CD137;CDw137;ILA

Description:

Recombinant human 4-1BB protein with C-terminal mouse Fc and 6×His tag

Background:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.

Molecular characterization:

41BB(Leu24-Gln186) mFc(Pro99-Lys330) 6×His

Molecular weight:

The protein has a predicted molecular mass of 54-60 kDa after removal of the signal peptide.

Tag:

C-Mouse Fc and 6×His Tag

Expression host:

HEK293

Target:

4-1BB

Purity:

The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Formulation / Reconstitution:

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.

Storage:

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

More info:

Email info@sobekbio.com

Orders:

Email orders@sobekbio.com