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Specifications
| 100 µL |
Alternative names:
apoptosis regulator,BCL2,IHC antibody,PPP1R50,B-cell CLL/lymphoma 2
Product info:
Bcl-2 mouse monoclonalProtein full nameApoptosis regulator Bcl-2SynonymsBCL2, Bcl-2, PPP1R50, B-cell CLL/lymphoma 2, apoptosis regulatorImmunogenKLH conjugated Synthetic peptidecorresponding to Mouse Bcl-2IsotypeIgGPurityAffinity purificationSubcellular locationMitochondrion outer membrane, Nucleus membrane, Endoplasmic reticulum membraneUniprot IDP10417, P10415, P49950ApplicationsApplicationsIHCIFSpeciesMouse, RatMouse, RatDilution1: 2000-1: 40001: 1000-1: 2000Positive tissuepneumonia, hepatitis, splenitispneumonia, hepatitis, splenitisBackgroundSuppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release. ImagesImmunohistochemistry analysis of paraffin-embedded mouse pneumonia using Bcl-2(GB12138) at dilution of 1:3000StorageStorageStore at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.Storage BufferPBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.NOTE:1.This product is intended for research only.2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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