Alternative names:

GPRC1A, MGLU1, MGLUR1, PPP1R85, SCA44, SCAR13

Description:

Human GRM1 full length protein-synthetic nanodisc

Background:

This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

Protein families:

GPCR,Transmembrane,Druggable Genome,

Protein pathways:

GPCRDB Class C Metabotropic glutamate pheromone,GPCRDB Other,

Expression host:

HEK293

Target:

GRM1

Molecular weight:

The human full length GRM1 protein has a MW of 132.4kDa

Formulation / Reconstitution:

Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.

Usage:

Research use only

More info:

Email info@sobekbio.com

Orders:

Email orders@sobekbio.com