Alternative names:

FZ-8, hFZ8

Description:

Human FZD8 full length protein-synthetic nanodisc

Background:

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]

Protein families:

Transmembrane,Druggable Genome,

Protein pathways:

Wnt NetPath 8,Wnt signaling,Wnt signaling and pluripotency,Cancer,Notch,Wnt Pathway,Stem Cell ,

Expression host:

HEK293

Target:

FZD8

Molecular weight:

The human full length FZD8 protein has a MW of 73.3kDa

Formulation / Reconstitution:

Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.

Usage:

Research use only

More info:

Email info@sobekbio.com

Orders:

Email orders@sobekbio.com