Alternative names:

FZ-6, FZ6, HFZ6, NDNC1, NDNC10

Description:

Human FZD6 full length protein-synthetic nanodisc

Background:

This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]

Protein families:

GPCR,Transmembrane,Druggable Genome,

Protein pathways:

Wnt NetPath 8,Wnt signaling,Wnt signaling and pluripotency,Cancer,Notch,Wnt Pathway,

Expression host:

HEK293

Target:

FZD6

Molecular weight:

The human full length FZD6 protein has a MW of 79.3kDa

Formulation / Reconstitution:

Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.

Usage:

Research use only

More info:

Email info@sobekbio.com

Orders:

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