Alternative names:

ADRB2R, ADRBR, B2AR, BAR, BETA2AR

Description:

Human ADRB2 full length protein-synthetic nanodisc

Background:

This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This receptor is also a transcription regulator of the alpha-synuclein gene, and together, both genes are believed to be associated with risk of Parkinson's Disease. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity, type 2 diabetes and cardiovascular disease. [provided by RefSeq, Oct 2019]

Protein families:

GPCR,Transmembrane,Druggable Genome,

Protein pathways:

Calcium regulation in cardiac cells,GPCRDB Class A Rhodopsin-like,GPCRDB Other,Monoamine GPCRs,Metabolic and Obesity,G-Protein Coupled Receptors Signaling Pathway,cAMP and Ca2 Signaling Pathway,

Expression host:

HEK293

Target:

ADRB2

Molecular weight:

The human full length ADRB2 protein has a MW of 46.5kDa

Formulation / Reconstitution:

Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.

Usage:

Research use only

More info:

Email info@sobekbio.com

Orders:

Email orders@sobekbio.com