Alternative names:

CALCRL; CRLR; LMPHM8

Description:

Human CGRPR-RAMP1 full length protein-synthetic nanodisc

Background:

The CGRP receptor (CGRPR) is a member of family B G protein coupled receptors (GPCRs), is expressed throughout the trigeminal system, including neurons and endothelial cells. They usually function with accessory proteins such as receptor activity modifying proteins (RAMPs) and Na/H exchange regulatory factors (NHERFs). CGRPR is a heterodimer complex of the calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1). Therapeutics for migraine treatment are mostly targeting CRLR-RAMP1 protein-protein interaction surfaces, thereby blocking CGRP activity.

Protein families:

Druggable Genome, GPCR, Transmembrane

Protein pathways:

Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction

Expression host:

HEK293

Target:

CGRPR

Molecular weight:

The human full length CGRPR protein has a MW of 53.0 kDa

Formulation / Reconstitution:

Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.

Usage:

Research use only

More info:

Email info@sobekbio.com

Orders:

Email orders@sobekbio.com