Alternative names:

HM2

Description:

Human CHRM2 full length protein-synthetic nanodisc

Background:

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

Protein families:

Druggable Genome, GPCR, Transmembrane

Protein pathways:

Calcium signaling pathway, Neuroactive ligand-receptor interaction, Regulation of actin cytoskeleton

Expression host:

HEK293

Target:

CHRM2

Molecular weight:

The human full length CHRM2 protein has a MW of 51.5 kDa

Formulation / Reconstitution:

Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.

Usage:

Research use only

More info:

Email info@sobekbio.com

Orders:

Email orders@sobekbio.com