Alternative names:

GLUT4

Description:

Human SLC2A4 full length protein-synthetic nanodisc

Background:

This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008]

Protein families:

Druggable Genome, Transmembrane

Protein pathways:

Adipocytokine signaling pathway, Insulin signaling pathway, Type II diabetes mellitus

Expression host:

HEK293

Target:

SLC2A4

Molecular weight:

The human full length SLC2A4 protein has a MW of 54.6 kDa

Formulation / Reconstitution:

Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.

Usage:

Research use only

More info:

Email info@sobekbio.com

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