Alternative names:

P2X7

Description:

Human P2RX7 full length protein-synthetic nanodisc

Background:

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]

Protein families:

Druggable Genome, Ion Channels: ATP Receptors, Transmembrane

Protein pathways:

Calcium signaling pathway, Neuroactive ligand-receptor interaction

Expression host:

HEK293

Target:

P2RX7

Molecular weight:

The human full length P2RX7 protein has a MW of 68.4 kDa

Formulation / Reconstitution:

Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.

Usage:

Research use only

More info:

Email info@sobekbio.com

Orders:

Email orders@sobekbio.com