Alternative names:

AC133; CD133; CORD12; MCDR2; MSTP061; PROML1; RP41; STGD4

Description:

Human PROM1 full length protein-synthetic nanodisc

Background:

A pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene.

Protein families:

Druggable Genome, ES Cell Differentiation/IPS, Transmembrane

Protein pathways:

N/A

Expression host:

HEK293

Target:

PROM1

Molecular weight:

The human full length PROM1 protein has a MW of 97.2 kDa

Formulation / Reconstitution:

Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.

Usage:

Research use only

More info:

Email info@sobekbio.com

Orders:

Email orders@sobekbio.com