Alternative names:

ANKTM1; FEPS; FEPS1

Description:

Human TRPA1 full length protein-synthetic nanodisc

Background:

The structure of the protein is highly related to both the protein ankyrin and transmembrane proteins. This protein is activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds. Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner, whereas mechanisms of non-electrophilic ligands are not well determined. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system.

Protein families:

Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane

Protein pathways:

N/A

Expression host:

HEK293

Target:

TRPA1

Molecular weight:

The human full length TRPA1 protein has a MW of 127.5 kDa

Formulation / Reconstitution:

Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.

Usage:

Research use only

More info:

Email info@sobekbio.com

Orders:

Email orders@sobekbio.com