Alternative names:

TNFRSF4;OX40;CD134;OX40L receptor;ACT35;TXGP1L

Description:

Recombinant human OX40 protein with C-terminal human Fc and 6×His tag

Background:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4 T cell response, as well as in T cell-dependent B cell proliferation and differentiation.

Molecular characterization:

OX40(Leu29-Ala216) hFc(Glu99-Ala330) 6×His tag

Molecular weight:

The protein has a predicted molecular mass of 47.2 kDa after removal of the signal peptide.

Tag:

C-Human Fc and 6×His Tag

Expression host:

HEK293

Target:

OX40

Purity:

The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Formulation / Reconstitution:

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.

Storage:

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

More info:

Email info@sobekbio.com

Orders:

Email orders@sobekbio.com